Convection-enhanced delivery for glioblastoma: targeted delivery of antitumor therapeutics
نویسندگان
چکیده
منابع مشابه
Convection-enhanced Delivery of Therapeutics for Malignant Gliomas
Convection-enhanced delivery (CED) circumvents the blood-brain barrier by delivering agents directly into the tumor and surrounding parenchyma. CED can achieve large volumes of distribution by continuous positive-pressure infusion. Although promising as an effective drug delivery method in concept, the administration of therapeutic agents via CED is not without challenges. Limitations of distri...
متن کاملConvection-enhanced delivery for the treatment of glioblastoma.
Effective treatment of glioblastoma (GBM) remains a formidable challenge. Survival rates remain poor despite decades of clinical trials of conventional and novel, biologically targeted therapeutics. There is considerable evidence that most of these therapeutics do not reach their targets in the brain when administered via conventional routes (intravenous or oral). Hence, direct delivery of ther...
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Carbon nanotubes (CNTs) are high aspect ratio allotropes of carbon. Because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. Their very low solubility is the only problem of them which is solved by different methods of Functionalization. After discoveries in the last few years of the capacity of CNTs to penetra...
متن کاملConvection-Enhanced Delivery for Targeted Delivery of Antiglioma Agents: The Translational Experience
Recent improvements in the understanding of glioblastoma (GBM) have allowed for increased ability to develop specific, targeted therapies. In parallel, however, there is a need for effective methods of delivery to circumvent the therapeutic obstacles presented by the blood-brain barrier and systemic side effects. The ideal delivery system should allow for adequate targeting of the tumor while m...
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ژورنال
عنوان ژورنال: CNS Oncology
سال: 2015
ISSN: 2045-0907,2045-0915
DOI: 10.2217/cns.15.12